Enhanced Chemiluminescent Substrate (Custom fill )

Chemiluminescence immunoassay (CLIA) is an assay that combines the chemiluminescence technique with immunochemical reactions, which is available for the detection and analysis of antigens, antibodies, enzymes, and drugs etc. In recent years, CLIA has gained increasing attention in various fields such as clinical diagnosis, environmental monitoring, and pharmaceutical analysis because of its safety, high sensitivity, and good specificity etc.

Depending on different luminescence mechanisms, CLIA includes direct chemiluminescence immunoassay, chemiluminescence enzyme immunoassay, and electrochemiluminescence immunoassay. Regarding chemiluminescence enzyme immunoassay, an enzyme, such as horseradish peroxidase (HRP), is first used to label an antigen or antibody, after immunoreaction, luminol as a luminescent substrate emits light by oxidation-reduction reaction under the action of the enzyme-labeled immune-reactant and the luminescent reagent, and then the antigen or antibody is determined by luminescent intensity.

 

Although light emission generated rapidly by the aforementioned reaction, the duration of luminescence is short, resulting in that the stability and reproducibility of the detection results are not good enough. Subsequent studies have found that the use of one or more chemical agents (enhancers) can increase the luminescent intensity and prolong the luminescence time.

Our reagent for performing a chemiluminescent reaction, which can not only effectively enhance the luminescent intensity, but also greatly increase the luminescence time.

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